Istaroxime
- Product Name
- Istaroxime
- CAS No.
- 203737-93-3
- Chemical Name
- Istaroxime
- Synonyms
- CS-1089;PST2744;PST 2744;PST-2744;Debio0614;Debio 0614;Istaroxime;PST2744/PST-2744;Istaroxime(PST2744);PST2744; PST 2744; ISTAROXIME; DEBIO 0614; DEBIO0614
- CBNumber
- CB71508601
- Molecular Formula
- C21H32N2O3
- Formula Weight
- 360.5
- MOL File
- 203737-93-3.mol
Istaroxime Property
- Boiling point:
- 511.1±60.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in H2O
- form
- Powder
- pka
- 9.49±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- A3507
- Product name
- Istaroxime
- Packaging
- 2mg
- Price
- $227
- Updated
- 2021/12/16
- Product number
- A3507
- Product name
- Istaroxime
- Packaging
- 5mg
- Price
- $340
- Updated
- 2021/12/16
- Product number
- A3507
- Product name
- Istaroxime
- Packaging
- 10mg
- Price
- $520
- Updated
- 2021/12/16
- Product number
- A3507
- Product name
- Istaroxime
- Packaging
- 50mg
- Price
- $1457
- Updated
- 2021/12/16
- Product number
- DC7151
- Product name
- Istaroxime(PST2744)
- Purity
- >98%
- Packaging
- 100mg
- Price
- $800
- Updated
- 2021/12/16
Istaroxime Chemical Properties,Usage,Production
Biological Activity
istaroxime is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (na+/k+ atpase). istaroxime is an investigational drug originally patented and developed by the italian pharmaceutical company sigma-tau. istaroxime is now under development for treatment of acute decompensated heart failure by cvie therapeutics.
in vitro
pst2744 inhibited the na+/k+-atpase activity from dog kidney with an ic50 value of 0.43 ± 0.15 μm [1]. the transient inward current (i(ti)) induced by a ca(2+) transient in the presence of complete na(+)/k(+) pump blockade was inhibited (-43%) by pst2744 but not by digoxin [2].
in vivo
intravenous infusion of 0.2 mg/kg/min pst2744 in anesthetized guinea pigs exerted an immediate and long-lasting inotropic effect (ed(80) of 1.89 +/- 0.37 mg/kg) without causing lethal arrhythmias up to a cumulative dose of 18 mg/kg [1]. istaroxime intravenous infusion (0.11 mg/kg per min) significantly increased both indices of contraction and relaxation (fractional shortening, +18+/-3.7%; aortic flow rate, +19+/-2.9%; peak myocardial systolic velocity, +36+/-7%; circumferential fiber shortening, +24+/-4.1%; peak atrial flow velocity, +69+/-8.6%; isovolumic relaxation time, +19+/-6.9%; and peak myocardial early diastolic velocity, +42+/-12%) [3]. in 5 animals, pst-2744 effects were compared with dobutamine. heart rates, pr intervals and qt intervals were unchanged following pst-2744 administration. pst-2744 increased contractility (+dp/dt) by 56% from 1881 +/- 282 mm hg/s to 2939 +/- 734 mm hg/s (p < 0.01) [4].
IC 50
0.43 ± 0.15 μm (na+/k+-atpase activity from dog kidney) [1]
Istaroxime Preparation Products And Raw materials
Raw materials
Preparation Products
Istaroxime Suppliers
- Tel
- +1-800-259-7612
- Fax
- +1-800-259-7612
- info@musechem.com
- Country
- United States
- ProdList
- 4662
- Advantage
- 60
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 19892
- Advantage
- 58
- Tel
- +1 (732)236-3202
- sales@cckinase.com
- Country
- United States
- ProdList
- 2738
- Advantage
- 58
- Tel
- 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 9926
- Advantage
- 65
View Lastest Price from Istaroxime manufacturers
- Product
- Istaroxime 203737-93-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Istaroxime 203737-93-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09